Prescription only · clinician reviewed
NAD+ Nasal Spray
NAD+ as a nasal spray, with clinician oversight and no needles.
Member pricing via Castle Rock Contouring
- Billed every 28 days
- Clinician review and care-team messaging included
- We'll bill this supply again when it's due. Complete the portal follow-up so the next fill can ship. You may still have medication on hand.
- Cancel anytime in your patient portal
Free eligibility check · $0 today · You are charged only if a clinician prescribes
Shipping and clinician visit added at checkout.
Choosing a plan starts an intake, not an order. A licensed clinician reviews it and decides whether to prescribe — they may decline, and you are not charged unless they approve.
NAD+ Nasal Spray
NAD+ as a nasal spray, with clinician oversight and no needles.
- No needles
- Clear focus
- Simple routine
Why people ask about it
What this is for
No needles
The usual reason people pick this form, and consistency matters more than delivery elegance.
Skips the digestive tract
Nasal absorption avoids the losses that make oral NAD+ unpredictable.
Simple to keep up with
Nothing to prepare and no supplies to manage.
Individual results vary. Your clinician decides whether it is right for you.
Before you start
What to know about NAD+ Nasal Spray
The same coenzyme as injectable NAD+, delivered as a nasal spray. Chosen by people who want NAD+ support without injecting.
- 01
NAD+ is a coenzyme central to energy metabolism and DNA repair, delivered here as a nasal spray instead of an injection.
- 02
Intranasal delivery is a genuine pharmacological route with real precedent, and it avoids needles entirely.
- 03
Trials reliably raise blood NAD+, and research into how that shows up in energy and function is active.
- 04
Prescription only, and supplied as a compounded medication, which means it is not FDA-approved.
Who this tends to fit
- You want NAD+ support without injecting
- You value a routine you will actually maintain
- You accept that nasal absorption is less well characterised
- You want clinician oversight throughout
Fitting the description does not mean you will be prescribed this. A clinician decides after reviewing your intake.
Supplied as a compounded medication, so it is not FDA-approved or FDA-reviewed for safety or effectiveness. The nasal route is chosen for convenience; the benefits described reflect what people commonly report.
The science
The science of NAD+ Nasal Spray
Tap a card to see the research behind each pathway.
How care works
What clinician oversight means here
Licensed clinicians, real review, and support after you start.
A licensed clinician decides
Your intake is reviewed by a clinician licensed in your state. They choose the treatment and the dose, and they can decline. Insert MD does not make that call.
Dispensed by a licensed pharmacy
Nothing ships without a prescription. Your order is prepared and sent by a licensed pharmacy, not packed by us.
Reviewed again at follow-up
Continuing is a decision, not a default. Your clinician reassesses whether the treatment still fits before you carry on.
Compounded is not FDA-approved
Several treatments here are compounded. The FDA does not review compounded medications for safety, effectiveness, or quality, and we say so on every page where it applies.
How it works
Three steps, no charge to find out
Check eligibility
A quick questionnaire — takes about 2 minutes. No charge to see if you qualify.
Provider review
A licensed clinician reviews your intake and approves an appropriate plan.
Delivered to you
Your treatment ships directly to your door, with care-team support.
Precise, consistent dosing
Your prescription is prepared by a licensed pharmacy and reviewed by a clinician licensed in your state. Nothing ships until they approve.
- Compounded by a licensed pharmacy
- Identity, potency, and purity tested
- Dose set by a licensed clinician
- Ships ready to use — no home mixing
Good to know
NAD+ is a coenzyme your mitochondria depend on to produce energy, and it is also used by DNA repair enzymes. Levels decline with age. A nasal spray is absorbed across the nasal lining, avoiding both needles and the digestive tract.
Supplied as a compounded medication, so it is not FDA-approved or FDA-reviewed for safety or effectiveness. The nasal route is chosen for convenience; the benefits described reflect what people commonly report.
- Known allergy or hypersensitivity to NAD+ components
- Active or previous cancer
- MTHFR mutation (route to prescribing provider)
- Pregnancy
- Low blood pressure
- Arrhythmias / heart conditions
- Anxiety disorders
Tell your clinician if this applies.
- Naturally occurring molecule with minimal side effects reported in many clinical contexts
Tell your clinician if this applies.
- Mild nausea
- Flushing
Your dose, schedule, and how long you stay on treatment are set by the prescribing clinician after reviewing your intake, and may differ from any general description here. General information, not medical advice.
Injection delivers more predictably. Nasal absorption is less well characterised, and neither route has strong outcome data. Your clinician can talk through the trade-off.
Nasal irritation or a brief odd taste are the usual complaints. Tell your care team if it persists.
A licensed clinician does, after reviewing your intake. Nothing on this page is a prescription or a promise of one, and your plan may look different from any general description here.
References
Scientific sources
The primary papers, for readers who want to go deeper.
- 1.Cantó C, Menzies KJ, Auwerx J. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 2015;22(1):31-53.
- 2.Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-41.
- 3.Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev. 2012;64(7):614-28.
- 4.Crowe TP, Greenlee MHW, Kanthasamy AG, Hsu WH. Mechanism of intranasal drug delivery directly to the brain. Life Sci. 2018;195:44-52.
- 5.Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7(7):e42357.
- 6.Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286.
- 7.Yoshino J, Baur JA, Imai SI. NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab. 2018;27(3):513-28.
Plain language
Terms you might hear
- Coenzyme
- A helper molecule an enzyme needs in order to do its job.
- Mitochondria
- Structures inside cells that turn nutrients and oxygen into usable energy.
- Redox balance
- The balance between oxidising and reducing reactions in a cell. Cells need it kept within a range, not pushed to one extreme.
- Oxidative stress
- What happens when reactive molecules outpace the systems that neutralise them, damaging cell components over time.
- Antioxidant
- A molecule that neutralises reactive species before they damage cell structures.
- Bioavailability
- How much of a dose actually reaches your bloodstream. It is the main reason route of administration matters.
- Compounded
- Prepared for an individual patient by a licensed pharmacy. Compounded medications are not FDA-approved.
Ready when you are
See if NAD+ Nasal Spray is right for you
A licensed clinician reviews your intake and decides. You are not charged unless they approve.
NAD+ Nasal Spray
$90.00 · $0 today